The Combination of Radiotherapy, Chemotherapy and Immunotherapy in High-Risk Localized Soft Tissue Sarcoma

This trial is studying a combination of radiation therapy, chemotherapy, and immunotherapy for people with high-risk localized soft tissue sarcoma — a cancer of the body's connective tissues (such as fat, muscle, and blood vessels) in the limbs or trunk that is large, hard to remove, or has come back after surgery. **You may be eligible if...** - You have confirmed soft tissue sarcoma (grade 2 or 3) such as liposarcoma, leiomyosarcoma, synovial sarcoma, or similar types - Your tumor is larger than 5 cm, or it has been determined to be borderline or unresectable - The cancer is localized to the limbs or trunk (no spread to distant organs) - This is your first time with this tumor or it has recurred locally after more than 2 months of being disease-free **You may NOT be eligible if...** - Your cancer has spread to other parts of the body (distant metastases) - You have a cancer type not listed (e.g., radiation-induced angiosarcoma) - You have serious organ problems or autoimmune conditions Talk to your doctor to see if this trial is right for you.