RecruitingNot ApplicableNCT05775939

PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial

PET Functional Imaging to Evaluate Cardiac Radiation Damage (EUCLID)

Sponsor

Thomas Jefferson University

Enrollment

20 participants

Start Date

Jan 20, 2023

Study Type

INTERVENTIONAL

Conditions

Esophageal Carcinoma Lung Carcinoma

Summary

This clinical trial examines positron emission tomography (PET)/computed tomography (CT) in evaluating cardiac radiation damage in patients with lung or esophageal cancer. As part of the treatment for lung or esophageal cancer, patients will undergo radiation therapy. Sometimes, during this treatment, the heart is also subjected to some radiation which could affect its function, either increasing or decreasing the function. It is not known the consequences of this change nor is it known if doctors can detect the changes associated with the radiation. Sarcoidosis FDG positron emission tomography (PET)-computed tomography (CT) scans are a common way to image cardiac inflammation and myocardial viability. This study may help doctors image the heart before, during and after radiotherapy to monitor any changes.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial (EUCLID) is using PET/CT scans — advanced imaging that combines detailed pictures of anatomy with metabolic activity — to detect and measure heart damage that can occur as a side effect of radiation therapy in people treated for lung or esophageal cancer. The goal is to find better ways to identify radiation-related heart injury early. **You may be eligible if...** - You are 18 or older with confirmed lung or esophageal cancer - You are about to receive radiation therapy with an estimated heart dose of at least 5 Gy - Your life expectancy is at least 3 months - You are willing to undergo PET/CT imaging as part of the study **You may NOT be eligible if...** - You cannot receive the imaging (e.g., claustrophobia, inability to lie still) - You are pregnant or breastfeeding - You cannot provide informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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