Gamma Light and Sound Stimulation to Prevent Dementia in Cognitively Normal People At Risk for Alzheimer's Disease

This trial is testing whether daily exposure to flickering light and sound at a frequency of 40 Hz (called gamma stimulation) can prevent or delay the development of Alzheimer's disease in people who are currently cognitively normal but are at higher genetic risk. This non-invasive sensory stimulation approach has shown promise in animal studies for reducing toxic amyloid plaques in the brain. **You may be eligible if...** - You are between 55 and 90 years old - You have an immediate family member with Alzheimer's disease - You are currently cognitively normal (based on standard memory and cognition tests) - You have elevated amyloid in the brain detected by a specific PET scan (PiB PET), suggesting early biological changes associated with Alzheimer's - Your blood amyloid level is low **You may NOT be eligible if...** - You already show signs of cognitive decline or early dementia - Your brain amyloid levels are outside the specified range - You have other neurological conditions - You have epilepsy or a history of seizures triggered by light Talk to your doctor to see if this trial is right for you.