Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
Dexmedetomidine for Programed Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia: A Randomized Controlled Double-blind Trial
Assiut University
60 participants
May 29, 2023
INTERVENTIONAL
Conditions
Summary
The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using dexmedetomidine in addition to low-dose bupivacaine and through measuring the total volume of local anesthetic received through patient controlled epidural analgesia per hour
Eligibility
Inclusion Criteria6
- Age 18 - 45 years
- Scheduled for normal vaginal delivery
- ASA physical status ӀI-IӀӀ.
- Singleton non-complicated pregnancy.
- At least 36 weak of gestation.
- Vertex presentation.
Exclusion Criteria9
- Patient refusal to epidural analgesia.
- History of cardiac, liver, or kidney diseases.
- History of allergy to amide local anesthetics or study medications.
- Any neurological problem.
- History of chronic opioid analgesic use.
- Any contraindication of regional anesthesia.
- Evidence of intrauterine growth restriction or fetal compromise.
- Failed or unsatisfactory analgesic block.
- Body mass index ≥40 kg/m2
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Interventions
Epidural analgesia with bupivacaine and dexmedetomidine
Locations(1)
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NCT05781854