Trivalent Salmonella Conjugate Vaccine (TSCV)

Exclusion Criteria11

• A history of documented hypersensitivity to any component of the Trivalent Salmonella Conjugate Vaccine or of Typbar-TCV™
• A history of previous vaccination with any licensed or experimental typhoid vaccine A known history of diabetes, tuberculosis, malignancy, chronic kidney disease, cardiac disease, liver disease, progressive neurological disorder, poorly controlled seizure disorder, or a terminal illness based on participant interview and review of screening laboratory results.
• Severe malnutrition: i.e., weight-for-length Z-score of less than - 3.
• Receipt of any other investigational intervention in the last 6 months
• Known HIV infection or other forms of immunocompromise
• Receipt of systemic immunosuppressive medication including systemic corticosteroids
• For Step 1A, for females of child-bearing potential, a positive pregnancy test at the time of enrollment.
• For Step 1B, any female child who has experienced menarche.
• Acute illness with or without fever (temperature \>38.0oC) is a temporary exclusion criterion. Enrollment may be postponed until 3 days after the illness has resolved.
• Positive malaria test is a temporary exclusion criterion. Participant may be enrolled 3 days after completing treatment.
• Any condition determined by the investigators to be likely to interfere with evaluation of the vaccine, to be a significant health risk to the participant, or to make it unlikely that the participant would complete the study