RecruitingNot ApplicableNCT05794152

Wenzhou Gestational Diabetes Cohort


Sponsor

Westlake University

Enrollment

300 participants

Start Date

Mar 21, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The Wenzhou Gestational Diabetes Cohort (WGDC) is a prospective cohort study among women with gestational diabetes mellitus (GDM) during pregnancy and their offspring living in Wenzhou, China. The primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with GDM over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. Another aim of the WGDC is to investigate the association of dietary and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, macrosomia and large-for-gestational-age birth. The secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 weeks among the patients with long-term metabolic health of the women and their offspring.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This cohort study is tracking women diagnosed with gestational diabetes mellitus (GDM) — a form of diabetes that develops during pregnancy — and following both the mother and child over time to understand its long-term health consequences. GDM affects blood sugar control during pregnancy and is linked to higher risks of complications during delivery, as well as increased chances of developing type 2 diabetes later in life for the mother, and metabolic or developmental issues for the child. By studying a large group of participants over four or more years, researchers hope to identify key risk factors and better understand how GDM impacts family health. Women aged 18 or older who are diagnosed with GDM at 24–28 weeks of pregnancy, plan to deliver at Wenzhou People's Hospital, and intend to remain in Wenzhou with their child for at least 4 years are eligible. Women with cancer or other serious pre-existing medical conditions are excluded. Participants will be monitored through pregnancy and the postnatal period, with follow-up assessments for both themselves and their children. This research is important because GDM is increasingly common globally, and understanding its downstream effects can guide better screening, prevention, and management strategies to improve health for generations of affected families.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERStandardized breakfast

Participants will be provided with a standardized breakfast on a morning of the days they wear a continuous glucose monitoring (CGM) device.

OTHERStandardized snack

Participants will be provided with a standardized snack 2 hour after they have the standardized breakfast.

OTHERStandardized lunch

Participants will be provided with a standardized lunch 2 h after they have the standardized snack.


Locations(1)

Wenzhou People's Hospital

Wenzhou, Zhejiang, China

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NCT05794152


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