RecruitingNot ApplicableNCT05794386

SCAR Burden of Left Atrium Guided cathEter Ablation sTrategy for Persistent Atrial Fibrillation

SCAR Burden of Left Atrium Guided cathEter Ablation sTrategy for Persistent Atrial Fibrillation (SCARLET-AF Study)

Sponsor

Seoul National University Hospital

Enrollment

204 participants

Start Date

Feb 1, 2023

Study Type

INTERVENTIONAL

Conditions

Atrial Fibrillation

Summary

This is a multicenter, randomized controlled trial to compare the recurrence of 1-year atrial arrhythmia after catheter ablation of atrial fibrillation (AF) between pulmonary vein isolation (PVI) and PVI with additional left atrial (LA) substrate modification based on the left atrial low-voltage area (LA LVA) in patients with persistent AF who had a moderate burden of LVA in LA (1cm2 to \<30%).

Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether mapping scar tissue in the heart before a catheter ablation procedure (a treatment that uses heat or cold to correct irregular heartbeats) can help doctors choose the best strategy for treating persistent atrial fibrillation (AFib — when the heart beats irregularly for a long time). **You may be eligible if...** - You are 19 or older - You have symptomatic persistent AFib (irregular heartbeat lasting more than 7 days) - Your AFib has not been controlled by medication - You are scheduled for a catheter ablation procedure - The amount of scar tissue in your heart's left upper chamber falls within a specific range (between 1 cm² and less than 30%) **You may NOT be eligible if...** - You have very little (under 1 cm²) or very extensive (30% or more) scar tissue — you may still be enrolled in a different group - Other cardiac or health conditions your doctor will review Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELVA-guided LA substrate modification

The LVA-guided additional LA ablation is included linear ablation or LVA zone border modification/isolation/ homogenization. The additional ablation strategies are finally selected at the physicians' discretion, considering LVA location and distribution.