Regorafenib Combined With Irinotecan Drug-Eluting Beads for Colorectal Cancer Liver Metastases

This study is testing a combination treatment — an oral chemotherapy drug (regorafenib) plus beads filled with a chemotherapy drug (irinotecan) injected directly into liver tumors — for colorectal cancer that has spread to the liver. **You may be eligible if...** - You are 18 or older - You have colorectal cancer that has spread to the liver (confirmed by imaging or tissue) - You have already tried two lines of standard chemotherapy that did not work - You have at least one measurable liver tumor larger than 1 cm - At least 80% of your cancer burden is in the liver **You may NOT be eligible if...** - Your cancer has spread extensively outside the liver - You have not yet tried first- and second-line chemotherapy - Other health or organ-function concerns apply Talk to your doctor to see if this trial is right for you.