RecruitingNot ApplicableNCT05795179

Stress & Self-Control Costs

Neural and Affective Mechanisms Underlying Prospective Self-control Costs


Sponsor

NYU Langone Health

Enrollment

300 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Summary

Self-control failures are a universal challenge for healthy and clinical populations. Recent work suggests these failures may arise from excessive cognitive costs associated with exercising self-control, yet the mechanisms underlying these costs are unknown. To address this, the investigators will use a validated decision-making task that measures how much individuals will pay (from a study endowment) to restrict access to tempting rewards that may lead to self-control failures. The investigators will examine these costs to identify their cognitive, neural and affective mechanisms. First, the investigators will identify the cognitive and computational mechanism that gives rise to self-control costs. Second, the investigators will characterize the neural correlates of self-control costs and identify neural mediators and connectivity patterns stemming from these costs. Finally, the investigators will examine how different classes of stressors (physical, social, or lifetime stress) shape the behavioral and neural representations of self-control costs.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

  • -70 years of age, able to speak, read, and write fluently in English
  • be willing and able to follow study procedures and provide informed consent.
  • Must additionally confirm they are on a diet to maintain/lose weight and are implementing/maintaining dietary changes.

Exclusion Criteria5

  • History of or medication for neurologic or psychiatric disease
  • High-blood pressure or heart condition
  • Diabetes, food allergies, metabolic disorders or history of eating disorder
  • Use of corticosteroids or beta-blockers
  • Metallic implants or devices contraindicating magnetic resonance imaging.

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Interventions

BEHAVIORALCold-Pressor Task (CPT)

CPT is a physiological stress task in which participants continuously submerge their hand and forearm in ice-water (0-4°C) for 3 minutes.

BEHAVIORALTrier Social Stress Test (TSST)

The TSST is a psychosocial stressor that requires participants perform a short speech and solve math problems in front of 2 evaluative judges.

BEHAVIORALModified Non-Stress CPT

The modified non-stress CPT involves participants continuously submerging their hand and forearm in warm water for 3 minutes.

BEHAVIORALModified Non-Stress TSST

For the modified non-stress TSST, participants are asked to prepare for a speech that they will practice alone to themselves and complete math problems alone on a piece of scrap paper.

DEVICEFunctional Magnetic Resonance Imaging (fMRI)

Participants will complete the self-control task in the fMRI scanner.


Locations(1)

NYU Langone Health

New York, New York, United States

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NCT05795179