RecruitingNCT05798624

Impact of a Previous CS on the Ongoing Pregnancy Rate in Single Euploid Frozen Embryo Transfer (ET)

To Study the Impact of a Previous Cesarean Section (CS) With / Without an Isthmocele on the Ongoing Pregnancy Rate in Single Euploid Frozen Embryo Transfer

Sponsor

ART Fertility Clinics LLC

Enrollment

1,050 participants

Start Date

May 1, 2023

Study Type

OBSERVATIONAL

Conditions

Infertility Implantation

Summary

As embryo ploidy is a crucial factor not only for implantation but also for maintenance of a pregnancy, the aim of this study is to evaluate the impact of the CS / isthmocele on the ongoing pregnancy rates and the implantation site in single euploid frozen embryo transfer, independent of the endometrial preparation approach.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 42 Years

Inclusion Criteria1

\- All participants undergoing a single euploid FET, independent of the endometrial preparation approach

Exclusion Criteria6

Intracavitary fluid during preparation for FET
Known anomaly of the uterus or the adnexae (e.g.: fibroids, polyps, hydrosalpinx, endometriosis, adenomyosis)
Embryo which was biopsied on day 7
Poor quality embryo which was transferred (Gardner criteria: AC / BC / CB, biopsied on day 6 and CC embryos from both, day 5 and day 6 biopsies, classified as "poor" quality embryos)
History of recurrent abortion
Antiphospholipid syndrome / autoimmune diseases

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Interventions

DIAGNOSTIC_TESTUltrasound between 6+0 and 6+7 weeks of pregnancy - With Isthmocele

Location of implantation of the GS (gestational sac) amended to Naji et al, defined as 3 possible implantation sites: (A: fundal, B: anterior, C: posterior) Size of isthmocele: * Depth of isthmocele * Width of isthmocele * Circumference of isthmocele Distance between isthmocele and outer cervical os (measured with the trace line) Distance between CS scar and outer cervical os (measured with the trace line) Size of gestational sac Measurements of the isthmocele size / circumference / distance between isthmocele / CS and outer cervical os

DIAGNOSTIC_TESTUltrasound between 6+0 and 6+7 weeks of pregnancy - Without Isthmocele

Location of implantation of the GS amended to Naji et al, defined as 3 possible implantation sites: (A: fundal, B: anterior, C: posterior) Distance between CS scar and outer cervical os (measured with the trace line) Size of gestational sac

DIAGNOSTIC_TESTUltrasound between 6+0 and 6+7 weeks of pregnancy

Location of implantation of the GS (gestational sac) amended to Naji et al, defined as 3 possible implantation sites (A: fundal, B: anterior, C: posterior) Size of gestational sac