RecruitingPhase 1NCT05798897

Safety and Preliminary Efficacy of MT-601 in Patients With Relapsed/Refractory Lymphoma

A Phase 1 Study of Patient-Derived Multi-Tumor-Associated Antigen-Specific T Cells (MT-601) Administered to Patients With Relapsed or Refractory Non-Hodgkin and Hodgkin Lymphoma (APOLLO)


Sponsor

Marker Therapeutics, Inc.

Enrollment

79 participants

Start Date

Jan 2, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a Phase 1 multicenter study with a Dose Escalation and Dose Expansion evaluating safety and efficacy of MT-601 administration to patients with Relapsed or Refractory Lymphoma. The starting dose administered is 200 x 10\^6 cells (flat dosing).


Eligibility

Min Age: 18 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the safety and early effectiveness of MT-601, a new type of T-cell therapy (an engineered immune cell treatment), in patients with lymphoma (a blood cancer) that has come back or has not responded to prior treatments. **You may be eligible if...** - You are 18 or older - You have relapsed or refractory lymphoma (lymphoma that came back or did not respond to treatment) - You are considered an appropriate candidate for experimental therapy by your treating doctor - You have signed informed consent and meet all protocol-specific health criteria **You may NOT be eligible if...** - Your lymphoma type or prior treatment history does not meet specific criteria - You have significant organ dysfunction or other conditions that make experimental therapy unsafe - Other exclusion criteria apply (your doctor will review in detail) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMT-601

Multi-antigen specific CD4+ andCD8+ T cells


Locations(7)

City of Hope

Duarte, California, United States

University of Colorado

Aurora, Colorado, United States

Colorado Blood Cancer Institute (Sarah Cannon)

Denver, Colorado, United States

University of Kansas Medical Center

Kansas City, Kansas, United States

Cornell

New York, New York, United States

Sarah Cannon Research Institute at St. David's South Austin

Austin, Texas, United States

University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, United States

View Full Details on ClinicalTrials.gov

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NCT05798897