RecruitingNCT05801380

Monitoring Drug Efficacy in Patients with Alzheimer's Disease

Monitoring Drug Efficacy Through Multi-omics Research Initiative in Alzheimer's Disease


Sponsor

University of the Philippines

Enrollment

60 participants

Start Date

Feb 14, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

This study will explore the different factors associated with drug response to acetylcholinesterase (AChE) inhibitor (donepezil) and NMDA receptor antagonist (memantine) in patients with Alzheimer's Disease.


Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is tracking how well Alzheimer's disease medications work in newly diagnosed patients by monitoring changes in their gut bacteria (microbiome) alongside standard memory testing. The goal is to see if gut health plays a role in how patients respond to treatment. **You may be eligible if:** - You are 65 years old - You have been newly diagnosed with mild or moderate Alzheimer's disease dementia - A neurologist has confirmed a probable Alzheimer's diagnosis - You have not yet started Alzheimer's medications (or have been off them for at least 3 months) - You live in the National Capital Region (Philippines) - You can read and understand English or Filipino **You may NOT be eligible if:** - Your dementia has a different cause, such as stroke or vascular disease - You have untreated depression or psychiatric disorders in the past 6 months - You have taken antibiotics in the past 3 months - You regularly use immune-suppressing medications, steroids, or certain stomach acid medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAChE inhibitor monotherapy

This is a drug treatment using Donepezil only

DRUGAChE inhibitor and NMDA receptor antagonist combination therapy

This is a drug treatment combining Donepezil and Memantine


Locations(1)

Philippine General Hospital

Manila, National Capital Region, Philippines

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NCT05801380


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