Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

This study is testing a highly personalized, daily-adapted form of radiation therapy (called adaptive radiotherapy, or ART) for men with low- or intermediate-risk prostate cancer — adjusting the radiation plan each day based on how the prostate has shifted or changed in the body. **You may be eligible if:** - You are 18 or older - You have been diagnosed with low or intermediate-risk prostate cancer confirmed by biopsy - Your prostate is not too large (80cc or less on MRI) - Your urinary symptoms are mild to moderate (IPSS score 15 or less) - You are in reasonably good health (ECOG 0–2) - You are able to complete questionnaires throughout treatment **You may NOT be eligible if:** - You already have significant bowel or bladder side effects from prior treatment - You have had prior pelvic radiation - You have had a TURP (prostate surgery through the urethra), HIFU, or prostate cryoablation - Your cancer has spread to lymph nodes or outside the prostate capsule - You have active inflammatory bowel disease - You cannot have an MRI or prostate fiducial marker placement Talk to your doctor to see if this trial is right for you.