RecruitingNCT05804643

Novel MRI Techniques on Evaluation of Lymphedema

Development and Optimization of Novel MRI Techniques on Evaluation of Therapeutic Effects for Lymphedema Secondary to Breast Cancer Treatment: An Integrated Study of Pre-clinical Animal Models and Clinical Follow-up

Sponsor

National Taiwan University Hospital

Enrollment

210 participants

Start Date

Apr 10, 2023

Study Type

OBSERVATIONAL

Conditions

Lymphedema of Upper Limb

Summary

In this project, the investigators aim to investigate the imaging approaches for breast cancer-related secondary lymphedema. The clinical study aims to optimize the conventional MRI methods for mapping lymphedema and assess the post-surgical therapeutic effects in longitudinal follow-up studies. Additionally, a normal imaging database of lymphedema MRI images will be established for future reference. For pre-clinical animal study, investigators aim to develop and integrate two novel MRI methods, including free water elimination diffusion MRI and diffusion kurtosis MRI techniques. By integrating clinical and pre-clinical studies, the investigators aim to establish a precise imaging tool for evaluating the therapeutic effects of lymphedema for following translational applications.

Eligibility

Min Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating new MRI imaging techniques to better diagnose and monitor lymphedema — swelling of the arm or limb — that develops in breast cancer survivors after surgery or radiation treatment. **You may be eligible if:** - You are an adult with breast cancer-related lymphedema (arm or limb swelling following breast cancer treatment) **You may NOT be eligible if:** - You are younger than 20 years old - You are pregnant - You have certain metallic implants or electronic devices in your body that are not safe for MRI, including: - Pacemakers or implantable heart defibrillators - Cochlear implants - Metallic fragments or bullets in your body - Drug infusion pumps - Neurostimulation systems - Certain other MRI-incompatible devices Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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