Allo HSCT Using RIC and PTCy for Hematological Diseases

This trial is studying a reduced-intensity stem cell transplant (using a gentler conditioning regimen and a post-transplant drug called cyclophosphamide to prevent graft-versus-host disease) for patients with blood cancers or other blood disorders who need a donor stem cell transplant. **You may be eligible if:** - You are between 0 and 75 years old and in reasonably good physical condition - A matching or half-matched donor is available (related sibling, matched unrelated donor, or a haploidentical relative) - You have a blood cancer or disorder, such as: - Acute myeloid leukemia (AML) in second remission, or certain high-risk first remissions - Acute lymphoblastic leukemia (ALL) in second remission or high-risk first remission - Other blood cancers or disorders as determined by your medical team - Your cancer is in remission with minimal or no detectable disease at the time of transplant **You may NOT be eligible if:** - You have active, uncontrolled cancer (not in remission) - Your general health or organ function is too poor for transplant - No suitable donor is available Talk to your doctor to see if this trial is right for you.