RecruitingPhase 2NCT05806996

A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Sponsor

Mayo Clinic

Enrollment

120 participants

Start Date

Jul 31, 2023

Study Type

INTERVENTIONAL

Conditions

This research is being done to find out whether intravenous magnesium is effective in the treatment of bladder spasms after urologic surgery.

Min Age: 18 Years

\- Be undergoing a bladder invasive procedure with or without planned urinary catheter on Mayo Clinic Gonda 7 Outpatient Procedure Center.

Are unable to grant informed consent or comply with study procedure.
Allergy or known sensitivity to magnesium or Renacidin.
Expected or high risk of bladder extravasation.
Ongoing atrial fibrillation prior to surgery.
Are undergoing emergency surgery.
Are pregnant.
Known hypermagnesemia.
Patients with neuromuscular weakness (e.g., Myasthenia gravis) due to magnesium's muscle weakening effect.
Patients with myocardial compromise or cardiac conduction defects because of magnesium's anti-inotropic effects.
Patients with renal insufficiency, glomerular filtration rate less than 30, since Magnesium is eliminated by the kidneys resulting in exaggerated rise in serum magnesium.
Patients with concomitant use of a calcium channel blocker since magnesium sulfate could act synergistically to suppress muscular contractility.

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DRUGMagnesium

Intravenous infusion, load 50 mg/Kg with infusion of 15 mg/Kg/hour

DRUGPlacebo

Equivalent volume of normal saline

Mayo Clinic in Minnesota

Rochester, Minnesota, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

NCT05806996