Prediction of Vascular Events After Major Non-Cardiac Surgery : an Observational Prospective Cohort Study
Nanfang Hospital, Southern Medical University
20,000 participants
Jul 1, 2022
OBSERVATIONAL
Conditions
Summary
This observational study includes patients at medium-to-high cardiovascular risks undergoing major noncardiac surgery, measures their baseline demographic and clinical characteristics, preoperative cardiac biomarkers and intraoperative surgery/anesthesia related data, and screens them for the occurrence of myocardial injury and major adverse cardiac events after surgery. The primary aim is to develop and validate a pre- and an immediate postoperative prediction model for occurrence of major adverse cardiac events.
Eligibility
Inclusion Criteria3
- Age ≥ 45 years;
- Undergoing major noncardiac surgery (expected procedure duration ≥2 h, expected length of postoperative stay ≥2 d);
- History of at least one cardiovascular disease (i.e., coronary artery disease, stroke, congestive heart failure, or peripheral arterial disease) or with at least two cardiovascular risk factors (i.e., hypertension, diabetes, chronic kidney disease, smoking in the past ≥2 years, ≥65 years of age, hypercholesterolemia, history of TIA, high-risk surgery (intrathoracic, intraperitoneal, or major vascular)).
Exclusion Criteria4
- History of acute cardiovascular events within 30 days prior to surgery;
- American Society of Anesthesiologists (ASA) physical status of 5 or greater;
- Previously enrolled in this study;
- Unable to understand or to sign informed consent.
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Interventions
High-sensitivity cardiac troponin T is measured within 7 days prior to surgery and at day 1 and day 2 after surgery. N-terminal pro-B-type natriuretic peptide is measured within 7 days before surgery.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05812248