Efficacy, Acceptability and Safety of Event-driven HIV PrEP Using TAF/FTC in MSM in Thailand and France.

This trial (conducted in Thailand and France) is testing an on-demand (event-driven) HIV prevention pill strategy using TAF/FTC — meaning you take medication around the time you expect to have sex, rather than every day — for gay and bisexual men at moderate HIV risk who have sex less frequently. **You may be eligible if...** - You were assigned male at birth and are 18 or older - You have sex with men - You test negative for HIV (4th generation test) - You have condomless anal sex, but on average no more than 2 days per month - You have had at least one higher-risk sexual behavior in the past 6 months (e.g., condomless sex with 2+ partners, or an STI) - You can anticipate your sexual activity in advance (to time the medication) **You may NOT be eligible if...** - You are HIV-positive - You have daily or very frequent sexual activity that would require daily PrEP instead - You cannot plan your sexual activity in advance Talk to your doctor to see if this trial is right for you.