Efficacy and Safety of High-dose Liposomal Amphotericin B for Disseminated Histoplasmosis in AIDS

This trial is testing whether a high-dose regimen of liposomal amphotericin B (a powerful antifungal medication) is more effective at treating disseminated histoplasmosis — a serious fungal infection that has spread through the body — in people living with HIV/AIDS. **You may be eligible if...** - You are an adult living with HIV (regardless of whether you are on antiretroviral therapy) - You have been diagnosed with disseminated histoplasmosis, confirmed by microscopy, culture, tissue biopsy, or a urine antigen test - You are admitted to one of the participating hospitals **You may NOT be eligible if...** - You do not have confirmed histoplasmosis - You are not HIV-positive - You have a central nervous system infection from a different cause that cannot be distinguished from histoplasmosis Talk to your doctor to see if this trial is right for you.