RecruitingNCT05815628

Next-Generation-Sequencing Approach to Neutropenic Sepsis

Sponsor

Boris Böll

Enrollment

400 participants

Start Date

Jun 5, 2024

Study Type

OBSERVATIONAL

Conditions

Febrile Neutropenia

Summary

The aim of this prospective, observational, non-interventional, multi-centre study of the diagnostic use of DISQVER in neutropenic patients with FN is to provide further evidence of the efficacy of an NGS-based approach for detecting bloodstream infection in neutropenic patients.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Age ≥18 years
Informed consent
Neutropenia defined as \<500 ANC (Absolute neutrophil Count)/µl or \<1000 WBC (White bloddcell Count)/µl if ANC is not available
Fever (with an onset \< 24h) or Sepsis (with an onset \<24h) Patients with a life-threatening - organ dysfunction caused by a dysregulated host response to a suspected or proven infection.

Exclusion Criteria4

Age \< 18 years
Refusal or inability to give consent Inability to give informed consent if no acceptable patient representative is available
Patients who had previously been included, but develop a new episode of fever during the same hospitalization, will not be included a second time
Death is deemed imminent and inevitable

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