RecruitingNCT05816850

Multilayer Biological Characterization of Advanced Follicular Lymphoma: a Translational Study From FIL_FOLL12 Trial

Sponsor

Fondazione Italiana Linfomi - ETS

Enrollment

654 participants

Start Date

Sep 19, 2023

Study Type

OBSERVATIONAL

Conditions

Follicular Lymphoma

Summary

This is a Multicenter, Retrospective, Biological study ancillary to FOLL12 trial to evaluate the role of EZH2 aberrations in patient with FL treated with immunochemotherapy. Moreover, several novel biomarkers of FL will be investigated.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study collects and analyzes biological samples — such as blood and bone marrow — from patients already enrolled in a clinical trial for advanced follicular lymphoma (a type of slow-growing blood cancer). Researchers want to study molecular markers in the samples to better understand how the cancer behaves and responds to treatment. **You may be eligible if...** - You are already enrolled in the FIL_FOLL12 clinical trial - You have blood, bone marrow, or tissue samples available for analysis **You may NOT be eligible if...** - You are not already participating in the FIL_FOLL12 trial - Required biological samples are not available Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTEZH2 mutations/CNAs by droplet digital PCR (ddPCR)

Test of EZH2 mutations/CNAs by droplet digital PCR (ddPCR) in peripheral blood and in unsorted bone marrow aspirate samples at enrolment

DIAGNOSTIC_TESTEZH2-derived gene expression signature by RNA-Seq

Test of EZH2-derived gene expression signature by RNA-Seq in a subset of diagnostic FFPE samples

Locations(26)

A.O. SS. Antonio e Biagio e Cesare Arrigo, S.C. Ematologia

Alessandria, Italy

Nuovo Ospedale degli Infermi, SSD Ematologia

Biella, Italy

ASST Spedali Civili di Brescia - Ematologia

Brescia, Italy

Azienda Ospedaliera Universitaria Policlinico - S. Marco, UOC di Ematologia

Catania, Italy

A.O. S. Croce e Carle, S.C. di Ematologia e Trapianto di Midollo Osseo

Cuneo, Italy

Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia

Florence, Italy

Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l'Oncologia, Ematologia e terapie cellulari

Genova, Italy

IRCCS Istituto Romagnolo per lo studio dei Tumori "Dino Amadori" - IRST S.R.L., Ematologia

Meldola, Italy

ASST Grande Ospedale Metropolitano Niguarda, SC Ematologia

Milan, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Ematologia

Milan, Italy

Azienda Ospedaliero-Universitaria Policlinico di Modena, U.O. Oncologia

Modena, Italy

Fondazione IRCCS San Gerardo dei Tintori - Ematologia

Monza, Italy

AOU Maggiore della Carità di Novara, SCDU Ematologia

Novara, Italy

Presidio ospedaliero "A. Tortora", U.O. Onco-ematologia

Pagani, Italy

A.O. Ospedali Riuniti Villa Sofia-Cervello, Divisione di Ematologia

Palermo, Italy

IRCCS Policlinico S. Matteo di Pavia, Divisione di Ematologia

Pavia, Italy

Ospedale Guglielmo da Saliceto, U.O. Ematologia

Piacenza, Italy

Grande Ospedale Metropolitano Bianchi Melacrino Morelli - Ematologia

Reggio Calabria, Italy

Ospedale degli Infermi di Rimini, U.O. di Ematologia

Rimini, Italy

Policlinico Umberto I - Università "La Sapienza", Istituto Ematologia -Dipartimento di Medicina Traslazionale e di Precisione

Roma, Italy

Istituto Clinico Humanitas, U.O. Ematologia

Rozzano, Italy

A.O.U. Città della Salute e della Scienza di Torino, Ematologia Universitaria

Torino, Italy

A.O.U. Città della Salute e della Scienza di Torino, S.C. Ematologia

Torino, Italy

A.O. C. Panico, U.O.C Ematologia e Trapianto

Tricase, Italy

Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), SOC Clinica Ematologica

Udine, Italy

Ospedale di Circolo - U.O.C Ematologia

Varese, Italy

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NCT05816850

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