Cadonilimab Plus Anlotinib for R/M/P Cervical Cancer
Cadonilimab Plus Anlotinib for Recurrent, Metastasis or Persistent Cervical Cancer
Zhongnan Hospital
35 participants
Feb 16, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to test a new treatment combination including cadonilimab, anlotinib and granulocyte-macrophage colony-stimulating factor (GM-CSF) in recurrent, metastasis and persistent cervical cancer. The main questions it aims to answer are: * The efficacy of this combination in R/M/P CC; * The tolerance of this combination in R/M/P CC; * Possible biomarker of treatment response for this combination. Participants will receive cadonilimab of 10mg/kg every three weeks at day 1, take anlotinib (12mg) orally in day 1 to day 14, then take a 7 days break and subcutaneously injection of GM-CSF (200ug) from day 1 to day 14, then also take a 7-days break. This treatment will continue until progression or intolerable toxicity or withdraw of participants and it will last for no longer than 2 years.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
All Participants will receive cadonilimab of 10mg/kg every three weeks at day 1
All Participants will take anlotinib (12mg) orally in day 1 to day 14, then take a 7 days break.
All Participants will have subcutaneously injection of granulocyte-macrophage colony-stimulating factor from day 1 to day 14, then take a 7 days break.
Locations(1)
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NCT05817214