RecruitingPhase 3NCT05819138

Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes


Sponsor

University of Colorado, Denver

Enrollment

60 participants

Start Date

Jun 21, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This trial plans to learn more about the effects of a medication, semaglutide, on cardiovascular function, kidney function, and insulin sensitivity in adults with type 1 diabetes. This medication has been effective in reducing cardiovascular disease and diabetic kidney disease and improving glucose control and BMI in adults with type 2 diabetes. This study aims to look at how well the medication works in people with type 1 diabetes. Semaglutide is not approved by the FDA to be used in this way. These procedures are considered to be experimental.


Eligibility

Min Age: 18 YearsMax Age: 49 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether semaglutide — a medication commonly used for type 2 diabetes and weight loss — can benefit younger adults with type 1 diabetes by improving heart health and kidney function. Because type 1 diabetes significantly increases the risk of heart and kidney disease, researchers want to see if semaglutide offers similar protective benefits as it does in type 2 diabetes. **You may be eligible if...** - You are between 18 and 49 years old - You have type 1 diabetes - You use an insulin pump or automated insulin delivery system - Your kidney function is acceptable (eGFR ≥ 45) - Your BMI is between 20 and 45 **You may NOT be eligible if...** - You have had a serious low blood sugar episode requiring help from another person in the past 6 months - You have a history of pancreatitis or thyroid cancer - You have very poor kidney function - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSemaglutide Pen Injector

Semaglutide injection

DRUGPlacebo

Semaglutide placebo injection


Locations(2)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

University of Washington Medicine Diabetes Institute (UWMDI)

Seattle, Washington, United States

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NCT05819138


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