Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure
Omega-3 Fatty Acid Modulation of Brown Adipose Tissue for Arctic Resilience
Indiana University
30 participants
Jun 12, 2023
INTERVENTIONAL
Conditions
Summary
This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.
Eligibility
Inclusion Criteria3
- Male and female, between the ages of 18 to 40 years.
- Body Mass Index (BMI) of 18.5 to 24.9 kg/m2
- Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ) and the Physical Activity Readiness Questionnaire (PAR-Q+)
Exclusion Criteria9
- History of smoking or recreational smoking, hyperlipidemia, hypertension/cardiovascular disease, diabetes, renal disease, neurological disease, metabolic disease, and bleeding disorders or delayed clotting time.
- Taking SSRI's (antidepressants and anxiety medication), ADD/ADHD medication, and chronically consume pain medication (Aleve, Tylenol, CBD, etc).
- Have or have had chronic disorders of the rectum (e.g., cancer, surgery, active hemorrhoids, etc.) or who currently have related acute conditions (diarrhea, constipation, etc.).
- Have or have had a diagnosis of disorders related to immune suppression and/or autoimmune disease.
- Are pregnant or planning on being pregnant.
- Resting blood pressure of \> 130mmHg systolic or 90 mmHg diastolic.
- Resting Pulse rate of \> 100 bpm.
- History of regularly consuming fish oil supplements and/or regularly eating more than one fish meal per week.
- Consuming more than one fish meal per week during the study.
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Interventions
For 12 weeks subjects will ingest 6 capsules per day of fish oil (7.8 g/day total omega--3 fatty acids: 3.75 g/day EPA and 1.5 g/day DHA)
For 12 weeks subjects will ingest 6 capsules per day of olive oil (each capsule contains 990 mg of olive oil)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05822141