Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes

This trial tests whether semaglutide — a weekly injection used for type 2 diabetes and weight management — can slow kidney disease progression in adults with type 1 diabetes who already show signs of early kidney damage (higher-than-normal protein in the urine). Kidney disease is a serious complication of type 1 diabetes, and there are currently few effective treatments. **You may be eligible if...** - You are an adult (18 or older) with type 1 diabetes for at least 5 years - Your urine tests show elevated protein levels (UACR ≥ 30 mg/g) on two recent measurements - Your kidney function is at least moderate (eGFR ≥ 30) - You are on stable doses of blood pressure and cholesterol medications **You may NOT be eligible if...** - You have type 2 diabetes - You have a history of pancreatitis or thyroid cancer - You are pregnant or planning to become pregnant - You have very poor kidney function or other serious health conditions Talk to your doctor to see if this trial is right for you.