Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
University of Florida
120 participants
Apr 15, 2024
INTERVENTIONAL
Conditions
Summary
Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.
Eligibility
Inclusion Criteria4
- Age 65+
- Objective executive function decline, based on standardized cognitive assessments.
- Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?"
- Ability to walking independently for 6 minutes (use of cane permitted)
Exclusion Criteria4
- Major cognitive disorder that interferes with independence
- Percentile score less than 10th percentile on standardized cognitive assessments
- Medications that are thought to influence tDCS neuroplasticity.
- Contraindications to tDCS or MRI.
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Interventions
aerobic walking exercise using complex (cognitively engaging) walking tasks
20 minutes of 2 milliamp transcranial direct current stimulation (tDCS) of prefrontal regions, delivered at each session
30 seconds of 2 milliamp transcranial direct current stimulation (tDCS) of prefrontal regions, delivered at each session
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05830942