Cognitive Dysfunction Clinical Trials

118 recruitingLast updated: June 17, 2026

There are 118 actively recruiting cognitive dysfunction clinical trials across 30 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1. Top locations include Islamabad, Pakistan, Fuzhou, Fujian, China, Charleston, South Carolina, United States. Updated daily from ClinicalTrials.gov.


Cognitive Dysfunction Trials at a Glance

118 actively recruiting trials for cognitive dysfunction are listed on ClinicalTrialsFinder across 6 cities in 30 countries. The largest study group is Not Applicable with 58 trials, with the heaviest enrollment activity in Islamabad, Fuzhou, and Charleston. Lead sponsors running cognitive dysfunction studies include Foundation University Islamabad, Dartmouth-Hitchcock Medical Center, and Beijing Tiantan Hospital.

Browse cognitive dysfunction trials by phase

Treatments under study

About Cognitive Dysfunction Clinical Trials

Looking for clinical trials for Cognitive Dysfunction? There are currently 77 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cognitive Dysfunction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cognitive Dysfunction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 118 trials

Recruiting
Not Applicable

Breast Cancer, Reasoning, and Activity Intervention

Breast CancerBreast NeoplasmsAnatomic Stage II Breast Cancer AJCC v8+3 more
Mayo Clinic160 enrolled1 locationNCT04816006
Recruiting

POCD After Major Gynecologic Surgery

Postoperative Cognitive DysfunctionPerioperative Neurocognitive Disorder
Fatihhan Zeytun72 enrolled1 locationNCT07589348
Recruiting
Not Applicable

Polyphenols and Cognitive Decline

Cognitive DysfunctionCognitive Decline
University of California, Los Angeles300 enrolled1 locationNCT06507254
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment

Chronic Lymphocytic Leukemia (CLL)Chronic Myeloid Leukemia, BCR-ABL1 PositiveDisease/Condition Name Cancer-related Cognitive Dysfunction
University of Rochester NCORP Research Base400 enrolled1 locationNCT07638007
Recruiting

The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy

Postoperative Neurocognitive DisorderCognitive FunctionsTotal Intravenous Anesthesia+6 more
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital60 enrolled1 locationNCT07637357
Recruiting

Vortioxetine for Cognitive Function in ALK-positive NSCLC Treated With Lorlatinib

Lung AdenocarcinomaDepressionCognitive Dysfunction+3 more
Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo24 enrolled1 locationNCT07633626
Recruiting
Not Applicable

Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Mobility LimitationCognitive DysfunctionFrail Elderly
University of Florida120 enrolled2 locationsNCT05830942
Recruiting
Not Applicable

Brain Stimulation and Cognitive Training for MCI

Mild Neurocognitive DisorderCognitive DysfunctionMild Cognitive Impairment (MCI)+2 more
Medical University of South Carolina50 enrolled1 locationNCT07526740
Recruiting

MOBility Disorders Assessment in Patients With Mild COGnitive Disorders

Cognitive Dysfunction
University Hospital, Lille417 enrolled2 locationsNCT05273125
Recruiting
Not Applicable

Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use

Cognitive DysfunctionPsychotic DisordersCannabis Use+5 more
Douglas Mental Health University Institute134 enrolled1 locationNCT05445180
Recruiting
Not Applicable

Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

Cognitive DysfunctionMemory Disorders in Old Age
University of California, Los Angeles70 enrolled1 locationNCT04558164
Recruiting
Early Phase 1

Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft.

post operative cognitive dysfunction
Minia University150 enrolled1 locationNCT06741566
Recruiting
Not Applicable

bWell-D Pilot Randomized Controlled Trial

Cognitive DysfunctionDepressive Disorder, Major
University of British Columbia40 enrolled1 locationNCT06546917
Recruiting

Post Operative Cognitive Dysfunction After Breast Surgery

post operative cognitive dysfunctionEmergence Delirium
University of Padova200 enrolled1 locationNCT03774420
Recruiting
Phase 1Phase 2

Stem Cell Therapy for Early Alzheimer's Disease

Cognitive Dysfunction
Paul E Schulz12 enrolled1 locationNCT06775964
Recruiting
Not Applicable

Hyperbaric Oxygen Therapy for Post-COVID-19 Syndrome

COVID19Neurocognitive Dysfunction
Assaf-Harofeh Medical Center91 enrolled1 locationNCT04647656
Recruiting

The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery

Postoperative Neurocognitive DisorderQuality of recoveryElderly Patients+5 more
Ziekenhuis Oost-Limburg80 enrolled1 locationNCT07200726
Recruiting
Not Applicable

Long COVID Brain Fog: Cognitive Rehabilitation Trial

Cognitive ImpairmentCognitive DysfunctionPost-Acute COVID-19 Syndrome+2 more
University of Alabama at Birmingham30 enrolled1 locationNCT06095297