Whole-course Immunonutrition Combined With Chemoradiotherapy±ICIs for Local Advanced Patients With Inoperable Esophageal Squamous Cell Carcinoma

This study is testing whether adding nutritional support (immunonutrition) throughout treatment improves outcomes for patients with locally advanced esophageal squamous cell carcinoma (a type of throat/food-pipe cancer) who are receiving chemoradiation — a combination of chemotherapy and radiation — that cannot be cured by surgery. The goal is to see if better nutrition helps patients tolerate treatment and live longer. **You may be eligible if...** - You are between 18 and 85 years old - You have been diagnosed with esophageal squamous cell carcinoma that cannot be surgically removed - You have not yet received any cancer treatment - Your cancer is at a specific stage confirmed by imaging - Your general health allows chemoradiation (ECOG score 0–2) **You may NOT be eligible if...** - You have a different type of esophageal cancer (such as adenocarcinoma or small-cell) - Your cancer is at a very early or very advanced stage - Your cancer is considered surgically removable - You have previously received chemotherapy or radiation Talk to your doctor to see if this trial is right for you.