RecruitingNCT05837260

Investigating Utility of ctDNA and Tumour Evolution in Advanced Thyroid Cancer

A Multicentre Prospective Study Investigating the Utility of ctDNA as a Biomarker of Disease Burden, Genetic Heterogeneity and Tumour Evolution in Advanced Thyroid Cancer

Sponsor

Royal Marsden NHS Foundation Trust

Enrollment

120 participants

Start Date

Mar 23, 2023

Study Type

OBSERVATIONAL

Conditions

Thyroid Cancer

Summary

Although most thyroid cancers are treated and cured successfully there are still 30% who recur after many years. This will eventually progress and at this point may become incurable with treatment options including complex and high risk surgery. The overall efficacy of systemic treatment in advanced thyroid cancer has a good initial response in most patients but not all. The study will collect tissues and blood samples for various protein analysis, nucleic acid extraction and live cell analysis in order to try and detect the presence of plasma ctDNA at baseline of eligible patients.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a blood test that detects tumor DNA fragments (called circulating tumor DNA or ctDNA) can be used to better monitor and predict disease progression in people with advanced thyroid cancer. This is an observational study — it does not change treatment, but collects blood and tissue samples alongside standard care. **You may be eligible if...** - You are 18 or older - You have one of the following types of thyroid cancer: radioiodine-refractory differentiated thyroid cancer, medullary thyroid cancer, or anaplastic (undifferentiated) thyroid cancer - You are either under surveillance, about to start treatment, or already on systemic therapy - You are willing to provide a tumor tissue sample (from a prior biopsy or a new one) **You may NOT be eligible if...** - You have had another invasive cancer within the past 5 years (except non-melanoma skin cancer or carcinoma in situ) - You are pregnant - You have another illness that would interfere with sample collection Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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