A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

This study is testing a new approach to radiation therapy for soft tissue metastases (cancer that has spread to soft tissue outside of the brain) in people with various types of advanced solid tumors, including breast, lung, gastrointestinal, bladder, kidney, melanoma, and sarcoma. The goal is to see if this radiation approach can help control these metastatic deposits and improve quality of life. **You may be eligible if...** - You are 18 or older with a confirmed advanced or metastatic solid tumor of one of the eligible types - You have at least one soft tissue metastatic site that measures at least 5 cm and requires palliative radiation - Your overall health is good (ECOG score 0–1) **You may NOT be eligible if...** - You are pregnant or breastfeeding - The site being treated has already received radiation therapy before - You have uncontrolled infections (including HIV), uncontrolled diabetes, or connective tissue diseases (e.g., lupus, scleroderma) - You are currently taking corticosteroids at high doses - You have another active second malignancy Talk to your doctor to see if this trial is right for you.