RecruitingPhase 2NCT05838521

A Study of Sacituzumab Govitecan (IMMU-132) in Patients With Recurrent or Persistent Cervical Cancer

A Phase II Evaluation of Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2-SN-38 Antibody-drug Conjugate in Patients With Recurrent or Persistent Cervical Cancer


Sponsor

Yale University

Enrollment

20 participants

Start Date

Jun 2, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This is a non-randomized Phase 2 study of sacituzumab govitecan (IMMU-132) in subjects with recurrent or persistent cervical cancer.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing sacituzumab govitecan, a targeted antibody-drug treatment, for people whose cervical cancer has come back or has not responded to prior treatment. The drug delivers chemotherapy directly to cancer cells using a homing molecule that targets a protein called TROP-2. **You may be eligible if...** - You have cervical cancer that has returned or is persisting after at least one prior chemotherapy regimen - Your cancer has been confirmed by imaging (CT or MRI) - You have a tumor tissue sample available for testing - You are in adequate health to tolerate treatment **You may NOT be eligible if...** - You have not had any prior chemotherapy (note: weekly cisplatin given alongside radiation does not count) - You have uncontrolled infections or serious medical conditions - You have received prior treatment with sacituzumab govitecan or similar agents - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSacituzumab govitecan

This is a non-randomized Phase 2 study of sacituzumab govitecan (IMMU-132).


Locations(2)

Smilow Cancer Hospital at Yale New Haven

New Haven, Connecticut, United States

Cleveland Clinic

Cleveland, Ohio, United States

View Full Details on ClinicalTrials.gov

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NCT05838521


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