Blood Cell RNA-Based Cancer Detection
A Blinded Prospective Study on Development and Validation of the Blood Cell RNA-Based Cancer Detection
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
5,000 participants
Feb 8, 2021
OBSERVATIONAL
Conditions
Summary
Early diagnosis of cancer may provide patients with more treatment options and hopefully prolong survival. The purpose of this multi-center study is to collect peripheral blood from newly diagnosed cancer patients and healthy donors to establish a blood cell RNA-based model for the differentiation of cancer patients and healthy donors. The area under the receiver operating characteristic (AUROC), sensitivity and specificity of the test in the early detection of multiple cancers will be measured.
Eligibility
Inclusion Criteria2
- Age 18 years or older
- Provide informed consent
Exclusion Criteria5
- Pregnancy or lactating women
- Received a blood transfusion within 1 month
- Received anti-cancer treatment within 3 years
- Known prior diagnosis of cancer
- Poor health status or unfit to tolerate blood draw
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Interventions
RNA sequencing of peripheral blood cells
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05839834