Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

This study is testing whether giving patients targeted treatments before surgery — based on the specific genetic makeup of their colorectal cancer — can improve outcomes. Rather than a one-size-fits-all approach, treatment is matched to specific gene mutations found in the tumor. **You may be eligible if...** - You are 18 or older - You have a confirmed diagnosis of colorectal cancer that can be surgically removed - Your cancer has a specific genetic mutation (such as BRAF, RAS, HER2, MSI, NTRK, or others) that matches one of the study treatments - You are in good general health (able to carry out daily activities) - You have not yet received treatment for this cancer **You may NOT be eligible if...** - You have already had chemotherapy or radiation for this cancer - Your cancer has spread to distant organs and is not removable - You have a serious heart condition, active infections, or other major health issues - You are pregnant or breastfeeding - You have had certain other cancers in the past 3 years Talk to your doctor to see if this trial is right for you.