RecruitingNot ApplicableNCT05849012

A Pilot Study Examining Low Sulfur Diet as Treatment for Persistent Symptoms in Quiescent Crohn's Disease


Sponsor

University of Michigan

Enrollment

20 participants

Start Date

Dec 12, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to learn about a low sulfur diet in patients with Crohn's disease. Study participants will be randomized to receive a low sulfur diet or usual diet for 8 weeks. Participants will work with study nutritionists and receive dietary educational materials. Participants will attend 2 in-person visits as well as 6 phone visits during the study. In addition, subjects will undergo testing, including a test to measure rectal sensation, a test to look for small intestinal bacterial overgrowth, and a test to measure leaky gut.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This pilot study is testing whether a low-sulfur diet can reduce lingering symptoms (like fatigue, bloating, and abdominal pain) in people with Crohn's disease that is currently in remission (inactive). Some researchers think sulfur-containing foods may contribute to ongoing gut symptoms even when inflammation is under control. **You may be eligible if...** - You have a confirmed diagnosis of Crohn's disease - Your Crohn's disease is currently quiet (in remission), confirmed by recent lab tests or colonoscopy - You still have ongoing gut symptoms despite your disease being inactive - You are willing to follow a modified diet for the study period **You may NOT be eligible if...** - You have active Crohn's disease inflammation - You have had major bowel surgery recently - You are currently on certain medications that could affect gut symptoms - You are pregnant or breastfeeding - You have a history of an eating disorder Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERLow Sulfur Diet

Subjects will be placed on a low sulfur diet for 8 weeks with the support of a nutritionist. In addition, participants will be asked to complete: surveys, lactulose-mannitol test, glucose hydrogen breath test, blood samples, visceral sensation test, 24-hour urine sample for sulfate level, provide stool samples, optional colonoscopy.

OTHERUsual Diet

Subjects will continue on their usual diet for 8 weeks. At the end of 8 weeks, if participants are interested, they will be offered treatment with low sulfur diet for 8 weeks with the support of a nutritionist. In addition, participants will be asked to complete: surveys, lactulose-mannitol test, glucose hydrogen breath test, blood samples, visceral sensation test, 24-hour urine sample for sulfate level, provide stool samples, optional colonoscopy.


Locations(1)

University of Michigan

Ann Arbor, Michigan, United States

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NCT05849012