A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function
Eligibility
Min Age: 18 YearsMax Age: 65 Years
Plain Language Summary
Simplified for easier understanding
This study is testing a new oral medication called povorcitinib — a drug that targets a specific immune signaling pathway (JAK1) — to see if it can reduce asthma attacks and improve breathing in people with moderate to severe asthma that is not adequately controlled by standard inhalers.
**You may be eligible if...**
- You have a confirmed asthma diagnosis requiring medium- to high-dose combination inhaler therapy for at least 12 months
- Your lung function is below 80% of what's expected (pre-bronchodilator FEV1)
- Your breathing improves with a bronchodilator (reliever inhaler), indicating reversible airflow limitation
- You have had at least 2 asthma attacks in the past year requiring oral steroids or hospitalization
**You may NOT be eligible if...**
- You have another primary lung condition (like COPD) as a separate diagnosis
- You are pregnant or breastfeeding
- You have a history of certain serious infections (like tuberculosis)
- You have significant heart, liver, or immune system problems
- You are a current smoker with more than 10 pack-years of smoking history
Talk to your doctor to see if this trial is right for you.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
DRUGpovorcitinib
povorcitinib
OTHERplacebo
placebo
DRUGICS-LABA
Background Therapy
Locations(83)
Allervie Clinical Research
Birmingham, Alabama, United States
Kern Allergy Medical Clinic, Inc
Bakersfield, California, United States
Integrated Research of Inland, Inc
Upland, California, United States
Qway Research
Hialeah, Florida, United States
Direct Helpers Research Center
Hialeah, Florida, United States
Care Research Inc
Miami, Florida, United States
Verus Clinical Research Corp
Miami, Florida, United States
Dr. de Armas Research Center, Llc
Miami, Florida, United States
Care Research Center, Inc
Miami, Florida, United States
Anderson Allergy and Asthma
Orlando, Florida, United States
Heuer Md Research Inc
Orlando, Florida, United States
Advanced Clinical Research Atlanta
Atlanta, Georgia, United States
Covenant Pulmonary Critical Care
East Point, Georgia, United States
Northshore Medical Group
Glenview, Illinois, United States
Henry Ford Hospital
Detroit, Michigan, United States
Aa Medical Research Center
Flint, Michigan, United States
Revive Research Institute
Southfield, Michigan, United States
Northwell Health Physician Partners
New Hyde Park, New York, United States
Pioneer Clinical Research Ny
New York, New York, United States
Montefiore Medical Center (Mmc)
The Bronx, New York, United States
Onsite Clinical Solutions, Llc Charlotte Central Office
Charlotte, North Carolina, United States
Temple University Hospital
Philadelphia, Pennsylvania, United States
Clinical Research of Rock Hill
Rock Hill, South Carolina, United States
Howland Allergy and Asthma Pllc Dba Orion Clinical Research
Austin, Texas, United States
Linq Research, Llc
Pearland, Texas, United States
Quality Assurance Research Center
San Antonio, Texas, United States
Fundacion Respirar
Buenos Aires, Argentina
Fundacion Cidea
Buenos Aires, Argentina
Mautalen Salud E Investigacion
Buenos Aires, Argentina
Care: Centro de Alergia Y Enfermedades Respiratorias
CABA, Argentina
INAER
Capitalfederal, Argentina
Centro de Medicina Respiratoria
Concepción del Uruguay, Argentina
Instituto de Medicina Respiratoria - Imer
Córdoba, Argentina
Fundacion Enfisema
Mar del Plata, Argentina
Centro Medico Dharma
Mendoza, Argentina
Polo de Salud Vistalba
Mendoza, Argentina
Fundacion Scherbovsky
Mendoza, Argentina
INSARES
Mendoza, Argentina
Centro Respiratorio Quilmes
Quilmes, Argentina
Centro Respiratorio Infantil
Rosario, Argentina
Instituto de Diagnostico Abc
Rosario, Argentina
Instituto Especialidades de La Salud Rosario
Rosario, Argentina
Instituto Medico de La Fundacion Estudios Clinicos
Rosario, Argentina
Centro Medico Respire
San Fernando, Argentina
Ierim Instituto de Enfermedades Respiratorias E Investigacion Medica
San Juan Bautista, Argentina
Ipr Instituto de Patologias Respiratorias
San Miguel de Tucumán, Argentina
Cimer - Centro Integral de Medicina Respiratoria Srl