Dose Escalation For INtraprostatic LEsions

This study is testing whether a higher, more targeted dose of radiation to specific areas within the prostate — while keeping the overall dose to surrounding tissue the same — can improve cancer control in men with intermediate- or high-risk localized prostate cancer. Advanced imaging and radiation technology makes it possible to precisely boost the dose to the most dangerous spots in the prostate. **You may be eligible if...** - You have a confirmed diagnosis of prostate cancer that has not spread outside the prostate (localized) - Your cancer is classified as unfavorable intermediate-risk or high-risk (based on Gleason score, PSA level, and tumor stage) - You are suitable for radiation therapy **You may NOT be eligible if...** - Your cancer has spread to lymph nodes or other organs - You have previously had radiation therapy to the pelvic area - You have a pacemaker or other implant that could interfere with treatment planning - You have inflammatory bowel disease or other conditions that would make pelvic radiation too risky - You are unable to complete the required follow-up visits Talk to your doctor to see if this trial is right for you.