RecruitingPhase 4NCT05851898

Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

The Role of SNRI's in the Prophylaxis of Depression in the First Year Following Lower Extremity Fragility Fractures in Geriatric Patients

Sponsor

Wake Forest University Health Sciences

Enrollment

100 participants

Start Date

Apr 8, 2024

Study Type

INTERVENTIONAL

Conditions

Depression in Old Age Fragility Fracture

Summary

The goal of this pilot study is to learn about the feasibility about prescribing anti-depressants at discharge in patients aged 50 years and older with a lower extremity fragility fracture. The main questions it aims to answer are: * What are the obstacles to enrolling patients and prescribing anti-depressants among older adults? * Is it possible to start prescribing SNRI medication upon discharge? * What is the prevalence of depressive symptoms amongst patients with different types of injuries and weightbearing status? * What is a transition of care plan for patients who have geriatric depression and require further care? Participants will: * Undergo screening using the Geriatric Depression Scale * Start on Duloxetine 30mg daily at time of discharge * Report medication compliance and complete re-screening monthly * Complete patient reported outcome measures and 3 months, 6 months, and 1 year * Receive a referral to behavioral health, primary care, or psychiatrist for evaluation if they screen positive at any timepoint

Eligibility

Min Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether an antidepressant medication (an SNRI — a type of mood-lifting drug) can help prevent depression in older adults who have broken a bone in their leg due to fragility (bones that break easily from minor injury) and needed surgery. **You may be eligible if...** - You are 65 years old or older - You recently had surgery to fix a broken leg or hip bone caused by a fragility fracture (a break from a minor fall or stress) **You may NOT be eligible if...** - You experienced multiple serious injuries at once (polytrauma) - Your bone broke due to cancer or another disease (pathological fracture) - You are currently on hospice care - You have already been diagnosed with a psychiatric disorder or dementia - You are already taking antidepressants (SSRIs or SNRIs) or mood-stabilizing medications - You have a serious life-limiting illness such as cancer - You cannot give your own consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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