Circulating Tumor DNA as Surgical Biomarker in Patients With PancrEatic Adenocarcinoma for Statement of Resectability

This study is examining whether measuring tiny fragments of cancer DNA circulating in the blood (called circulating tumor DNA or ctDNA) before and during surgery can help doctors better predict whether pancreatic cancer can be completely removed and whether it might come back afterward. **You may be eligible if...** - You are 18 or older - You have been diagnosed with pancreatic cancer (PDAC) and your doctors believe surgery to remove it may be possible - Your cancer has been confirmed as non-metastatic (not spread to distant organs) on a CT scan - You are able to give informed consent **You may NOT be eligible if...** - Your cancer turns out to be unresectable (unable to be removed) at the time of surgery - You have serious uncontrolled heart conditions (heart failure, unstable angina, recent heart attack) - You have very high blood pressure that cannot be controlled with medication - You have serious liver failure or a major active infection Talk to your doctor to see if this trial is right for you.