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RecruitingNot ApplicableNCT05854654

Air Leak Detection and Treatment

Defining Novel Strategies for the Diagnosis and Treatment of Intraoperative Air Leaks: An Ex-Vivo Human Lung Model Study

Sponsor

Centre hospitalier de l'Université de Montréal (CHUM)

Enrollment

200 participants

Start Date

May 2, 2023

Study Type

INTERVENTIONAL

Conditions

Air Leak From Lung

Summary

Developing a methodology to detect, quantify and treat air leaks intraoperatively using a bio-adhesive, to thereby reduce postoperative surgical complications, morbidity, and length of stay for patients undergoing pulmonary resection.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new device or technique to detect and treat air leaks in transplanted lungs, which is a common complication after lung transplant surgery. It involves studying donor lungs that are not suitable for transplantation. **You may be eligible if...** - You are undergoing a lung transplant surgery, OR - You are an organ donor whose lungs are not eligible for transplantation (for ex vivo testing purposes) **You may NOT be eligible if...** - You are a healthy individual not involved in lung transplant procedures Talk to your doctor to see if this trial is right for you.

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Interventions

DIAGNOSTIC_TESTAir Leaks

The organs will be placed in an acrylic box and will be kept at a temperature of 37 Celsius degrees. The lungs will be mechanically ventilated connected by an endotracheal tube size 8 inserted in the bronchus with the balloon inflated and a silk suture providing an hermetic closure proximal to the balloon. This setting will allow us to perform several different endoscopic and RAB procedures in emulated physiologic conditions to complete the study.

Locations(1)

CHUM

Montreal, Quebec, Canada

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NCT05854654

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