RecruitingNot ApplicableNCT05854706

The Effect of Theta-burst Stimulation on Serum BDNF

Antidepressant Effect of Prolonged Intermittent Theta-burst Stimulation on Serum Brain-derived Neurotrophic Factor Levels of Patients With Depression: A Randomized, Double-Blind, Sham-Controlled Study

Sponsor

Taipei City Hospital

Enrollment

60 participants

Start Date

Apr 17, 2023

Study Type

INTERVENTIONAL

Conditions

Gambling Disorder

Summary

The goal of this clinical trial is to investigate the effect of theta burst stimulation for depression and serum brain-derived neurotrophic factor (BDNF) in individuals with major depression. The main question it aims to answer is whether 10 sessions of theta burst stimulation can influence the serum level of BDNF. Participants will be randomized into active group and sham group. Researchers will compare the level of BDNF in these groups.

Eligibility

Min Age: 20 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether a type of non-invasive brain stimulation called Theta-Burst Stimulation (TBS) — a form of transcranial magnetic stimulation (TMS) — changes levels of a brain protein called BDNF in the blood of people with depression. BDNF plays a role in brain health and mood regulation. **You may be eligible if...** - You are between 20 and 65 years old - You have been diagnosed with Major Depressive Disorder (clinical depression) according to standard diagnostic criteria **You may NOT be eligible if...** - You have schizophrenia, bipolar disorder, or depression with psychotic features - You have an active substance use disorder (other than nicotine use or light use of sleep aids) - You have a pacemaker, cochlear implant, or other implanted medical device controlled by the body's signals - You have pre-existing noise-induced hearing loss or are on medications that damage hearing - You have uncontrolled diabetes, unstable heart disease, or recent stroke - You take medications that lower the seizure threshold (such as certain antidepressants or antipsychotics) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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