RecruitingNCT05862389

Study on the Mechanism of Eating Disorder

Sponsor

Peking University

Enrollment

750 participants

Start Date

Sep 1, 2022

Study Type

OBSERVATIONAL

Conditions

Anorexia Nervosa Bulimia Nervosa

Summary

Eating disorders (EDs) are severe chronic psychiatric disorders with a not fully understood etiopathogenesis. Previous studies have revealed some biological mechanisms of EDs. However, the etiology and maintenance mechanism of EDs, especially the neuro-mechanisms is still unknown. To explore the pathogenic mechanism and treatment biomarkers of EDs, we design this study. the multidimensional data including the clinicopathological features, neuroimaging data (functional and structural magnetic resonance imaging), electroencephalogram and inflammatory cytokines will be used to investigate the biomarkers for diagnosis and treatment effectiveness.

Eligibility

Min Age: 13 YearsMax Age: 35 Years

Inclusion Criteria11

Anorexia nervosa
Anorexia nervosa according to Diagnostic and Statistical Manual of Mental Disorders (5th edition) (DSM-5);
Age: 13-35 (including 13 and 35)
BMI: 13-17.5kg/m\^2
The participants and/or their legal guardians ( for participants who are younger than 18-year-old) sign the informed consent form voluntarily and agree to participate in all visits and examinations as required by the trial protocol.
Do not take any psychiatric medications in past one month.
Bulimia nervosa
Bulimia nervosa according to Diagnostic and Statistical Manual of Mental Disorders (5th edition) (DSM-5);
Age: 13-35 years old (including 13 and 35)
The participants and/or their legal guardians ( for participants who are younger than 18-year-old) sign the informed consent form voluntarily and agree to participate in all visits and examinations as required by the trial protocol.
Do not take any psychiatric medications in past one month.

Exclusion Criteria6

Patients who meet DSM-5 diagnostic criteria for other mental disorders: Major depressive disorder, anxiety, obsessive-compulsive disorder, personality disorder, mental retardation; drug and/or alcohol dependence;
Patients who receive repetitive Transcranial Magnetic Stimulation (rTMS) or modified electroconvulsive therapy (MECT) treatment in past six months.
Patients with severe suicidal tendencies or suicidal behavior
Pregnant or lactating women;
Patients with MRI contraindications;
Patients who are regarded as unsuitable by investigators for this clinical trial.