Discontinuation Study

This study (Discontinuation Study) looks at what happens when people with multiple myeloma (a blood cancer) who have been in deep remission for at least 2 years on maintenance therapy stop taking that treatment — to understand whether it is safe to discontinue. **You may be eligible if...** - You are 18 or older - You have multiple myeloma and are currently in your first line of treatment - You have completed at least 2 years of maintenance therapy (or less if stopped due to side effects, but achieved a deep remission confirmed by MRD-negative testing) - You are willing to comply with the study schedule **You may NOT be eligible if...** - You have received more than one line of therapy for myeloma - You have not completed two years of maintenance therapy (unless you achieved sustained MRD-negative remission) - You have a different plasma cell disorder (e.g., Waldenstrom's, amyloidosis) - You have had an organ transplant or require ongoing immune-suppressing medication Talk to your doctor to see if this trial is right for you.