Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Quantitative Computed Tomography to Assess Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection
Tufts Medical Center
40 participants
Jun 5, 2023
OBSERVATIONAL
Conditions
Summary
Prospective cohort study to evaluate the utility of quantitative CT analysis to assess ventilation and perfusion defects in patients with Post-acute Sequelae of SARS-CoV-2 (PASC) and functional limitations
Eligibility
Inclusion Criteria4
- Age ≥ 18
- Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing \> 3 months ago or no previous history of SARS-CoV-2 infection (control group only)
- Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)
- New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only)
Exclusion Criteria7
- SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months
- Inability to provide consent or non-English speaking
- Pregnancy
- Any respiratory infection in last 4 weeks
- PFT relative contraindications
- History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism
- Active malignancy undergoing treatment or history of malignancy involving the lung
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Interventions
Quantitative Computed Tomography of the chest in the inspiratory and expiratory phases will be performed to assess regional lung ventilation as well as pulmonary vascular volume and distribution
Locations(1)
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NCT05866952