Creation of a Multicenter National Registry for Peripartum Cardiomyopathy.
Creation of a Multicenter National Registry for Peripartum Cardiomyopathy: a Wide, Multidisciplinary and Translational Perspective to Achieve Personalized Medicine for a Rare Disease in Women
Federico II University
40 participants
Feb 21, 2024
OBSERVATIONAL
Conditions
Summary
Peripartum cardiomyopathy (PPCM) is a rare, severe and potentially life-threatening disorder of largely unknown etiology and pathophysiology, with unexplained geographical differences and heterogeneous presentation. Investigators hypothesize that a network-based multidisciplinary strategy integrating clinical and molecular phenotyping of PPCM patients might anticipate diagnosis, optimize treatments, and identify novel mechanisms to achieve the unmet goal of personalized medicine.
Eligibility
Inclusion Criteria2
- Development of HF signs or symptoms in the last month of pregnancy or within 5 months of delivery;
- Left ventricle systolic dysfunction demonstrated by classical echocardiographic criteria (LVEF< 45 %) in the last month of pregnancy or within 5 months of delivery.
Exclusion Criteria2
- Presence of any identifiable cause of HF;
- Presence of recognizable heart disease before the last month of pregnancy.
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Interventions
Molecular and genetic screening
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05878041