RecruitingNot ApplicableNCT05878665

Low-dose Contrast Media for Low-kVp Abdomen CT

Optimizing Low-dose Contrast Media Protocol for Low-kVp Abdominopelvic CT in Suspected Acute Appendicitis

Sponsor

Bohyun Kim

Enrollment

292 participants

Start Date

Dec 21, 2023

Study Type

INTERVENTIONAL

Conditions

Appendicitis Acute

Summary

The purpose of this clinical study is to test the performance of low radiation dose abdominal CT combined with low dose contrast media for the diagnosis of acute appendicitis in young patients. The main questions to be answered are: 1, Can low-dose contrast media paired with low-dose radiation CT of the abdomen provide acceptable diagnostic accuracy in acute appendicitis? 2. How much radiation dose can be saved by using low radiation dose abdominal CT in combination with low dose contrast media?

Eligibility

Min Age: 19 YearsMax Age: 44 Years

Inclusion Criteria2

Patients in the emergency department with suspected acute appendicitis based on clinical examination
Patients scheduled for contrast-enhanced CT of the abdomen and pelvis for diagnosis of suspected acute appendicitis.

Exclusion Criteria3

Patients who decline to participate
Contraindications to contrast-enhanced CT (eGFR \< 30 mL/min/173 m\^2 or pregnant)
BMI \>= 30.

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Interventions

DIAGNOSTIC_TESTWeight-adjusted low-dose contrast media paired with low-radiation dose abdomen CT

The investigators are aiming for a 10% reduction in iodine dosage at 10 kVp reduction in CT radiation. Routine iodine dosing is 0.521 g I/kg at 120 kVp. Therefore, at 90 kVp, a 30% reduction in iodine dosing is expected, which is 0.365 g I/kg. At 100 kVp, the iodine dosage is reduced to 0.417 g I/kg, which is a 20% reduction. The kVp value is automatically selected by the CT device according to the body habitus, which is a clinical routine.