RecruitingNot ApplicableNCT05881642

Robot-assisted Function-sparing Cystectomy Followed by Modified Orthotopic Ileal Neobladder

Robot-assisted Cystectomy With Prostate and Seminal-sparing Technique Followed by Modified Orthotopic Ileal Neobladder


Sponsor

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Enrollment

20 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

With the same tumor control rate as classic radical cystectomy, radical cystectomy with partial preservation of the prostate and seminal vesicle can effectively preserve penile erection and fertility, improve urinary control rate and shorten hospitalization time. In this project, transurethral resection of the prostate was used to remove part of the prostate, which further reduced the trauma of radical cystectomy and better preserved the nerves and urethral sphincter. Rapid intraoperative examination of resected tissue can provide a basis for the selection of surgical options. Robot-assisted radical cystectomy can perform pelvic lymph node dissection more accurately, preserve neurovascular complex more effectively, and improve the control effect of tumor and the protective effect of sexual function and reproductive function. In view of the shortcomings of the internationally accepted orthotopic ileal neobladder, this study improved the operation according to the physiological and anatomical characteristics, restored the orthophoria of the new bladder, maintained the consistency of physiological anatomy, and minimized the bladder pressure.


Eligibility

Sex: MALEMin Age: 20 YearsMax Age: 70 Years

Inclusion Criteria4

  • Muscle invasive or recurrent multiple non-muscle invasive bladder cancer patients
  • Invasive bladder cancer patients without invasion of the triangle and posterior urethra
  • Age < 70 years old, urethral sphincter function is good
  • Male patients with serum prostate specific antigen < 4ug / L

Exclusion Criteria7

  • Possible recurrence of urethra after cystectomy
  • Patients with bladder adenocarcinoma and squamous cell carcinoma should not undergo orthotopic neobladder.
  • Patients with renal insufficiency
  • Severe liver dysfunction
  • Severe intestinal diseases ( Crohn 's disease, short bowel syndrome )
  • Preoperative tumor breaks through the bladder and invades the surrounding tissue
  • urethral stricture cannot pass through the resectoscope

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Interventions

PROCEDUREProstate and seminal-sparing Cystectomy

Adopt endoscopic enucleation technology to preserve the prostate capsule and part of the urinary control support structure to help restore urinary control and erectile functions

PROCEDUREConventional Radical Cystoprostatectomy

According to the consensus standard program, remove the accessory tissues including the bladder,prostate and seminal vesicles


Locations(1)

Union hospital,Tongji medical college, Huazhong university of science and techonology

Wuhan, Hubei, China

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NCT05881642