Confirming Permanent Lack of Blood Flow to the Brain During A-NRP DCC Organ Transplant
Confirming the Permanent Cessation of Intracranial Circulation During Abdominal Normothermic Regional Perfusion After the Determination of Death by Circulatory Criteria
Western University, Canada
30 participants
Apr 2, 2024
OBSERVATIONAL
Conditions
Summary
This study aims to evaluate the surgical technique used in Abdominal Normothermic Regional Perfusion (A-NRP) in death determination by circulatory criteria (DCC) organ donors. The proposed study will demonstrate that there is no resumption of brain blood flow or activity during the A-NRP procedure. This will be assessed using multimodal neuromonitoring protocol that enables continuous focused monitoring of brain blood flow and activity during A-NRP. This will provide evidence that brain blood flow and activity does not resume during NRP and ensure donor safety in using this technique in standard of care practice.
Eligibility
Inclusion Criteria1
- ≤ 18 years of age
Exclusion Criteria3
- \< 18 years of age
- DCC donors who proceed to donation following medical assistance in dying or those who are able to provide first-person consent at the time of donation
- Injuries that anatomically preclude the use of neurological monitoring
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Interventions
Multimodal neuromonitoring will include: Transcranial colour-coded Doppler (TCCD), Electroencephalography (EEG), and Somatosensory evoked potentials (SSEP) or brainstem auditory evoked potentials (BAEP)
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05884736