Novel Targetable BIOmarkers in ANorexia NervosA
Novel Targetable BIOmarkers in ANorexia NervosA - BIOANNA
University Hospital, Basel, Switzerland
32 participants
May 1, 2023
OBSERVATIONAL
Conditions
Summary
The overall aim of this present study is to evaluate Growth Differentiation Factor-15 (GDF-15) and inflammatory cytokines as a possible novel and readily treatable target for the successful therapy of Anorexia Nervosa (AN). Therefore, GDF-15, neuronal and glial damage markers such as Neurofilament light chain (Nfl) and Glial fibrillary acidic protein (GFAP) and cytokines (such as Tumor necrosis factor alpha (TNF-α), Interleukin-6 (IL-6), and Interleukin 1β (IL-1β) levels will be assessed in the serum as well as in the cerebrospinal fluid of patients with diagnosed restrictive AN with and without exercising behavior compared to sex- and age-matched healthy controls to consolidate previous findings and to identify the main site of production of GDF-15 and cytokines in AN.
Eligibility
Inclusion Criteria12
- N=8 adult male and female patients with confirmed diagnosis of anorexia nervosa restrictive type, non-exercising subtype
- Age 18-60 years
- Written informed consent
- BMI 10-16 kg/m2
- N=8 adult male and female patients with confirmed diagnosis of anorexia nervosa restrictive type, exercising subtype will be included in this study.
- Age 18-60 years
- Written informed consent
- BMI 10-16 kg/m2
- N=16 control participants, sex- and age-matched to the individual anorexia nervosa patients.
- Age 18-60 years
- Written informed consent
- BMI 19-24.9 kg/m2
Exclusion Criteria10
- Use of antibiotics within the last 31 days
- Current illicit drug abuse including daily marijuana or CBD (cannabidiol) consumption (≤ 24 g of alcohol per day allowed)
- Any kind of severe chronic disease other than AN (e.g. active cancer disease)
- Severe renal impairment (e.g. estimated glomerular filtration rate <30 ml/min/m2) if resulting from another disease than AN
- Known liver cirrhosis or other severe liver impairment if resulting from another disease than AN
- Acute upper respiratory tract infection within the last 31 days
- Uncontrolled dysthyroidism
- Uncontrolled hypertension
- Current pregnancy/lactation or current treatment for in vitro fertilization
- Inability to understand the study information, to sign the consent form and to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05885724