RecruitingNot ApplicableNCT05888467

Physical Activity and Cardiovascular Profile of Pre-conceptional Women At Risk for GHD

The Impact of Physical Activity on the Cardiovascular Profile of Pre-conceptional Women At Risk for Developing Gestational Hypertensive Disorders in Subsequent Pregnancy.

Sponsor

Hasselt University

Enrollment

140 participants

Start Date

May 15, 2023

Study Type

INTERVENTIONAL

Conditions

Gestational Hypertension Cardiovascular Pregnancy Complication

Summary

To compare the cardiovascular profile of pre-conceptional women at risk for developing Gestational Hypertensive Disorders in subsequent pregnancy before and after physical activity.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 50 Years

Inclusion Criteria8

Women at risk for the development of GHD in subsequent pregnancy based on the presence of at least one of the following risk factors:
high body mass index (BMI\>30 kg/m²)
a family history of PE (mother, sister)
in the need of assisted reproduction techniques in a previous or subsequent pregnancy
maternal comorbidities: prior PE, diabetes mellitus, chronic hypertension, chronic kidney disease or antiphospholipid syndrome
Non-pregnant (as confirmed by a negative pregnancy urine dipstick test)
Age ≥ 18 years
Being able to understand the Dutch language

Exclusion Criteria5

Participants eligible for this study must not meet any of the following criteria:
Pregnant at inclusion
Not being able to exercise according to physician's decision
Suffering from underlying diseases that can affect the CV profile such as oncological diseases coronary heart disease, aortic disease, peripheral arterial disease
Participating in another clinical study that may alter the results of this study

Interventions

OTHERsupervised infrared exercise group

Participants of the intervention group will be asked to perform 1-3 exercise sessions per week at the Infraligne center of Genk, Hasselt or Maasmechelen for a total duration of 12 weeks. During the exercise session, the participant is assigned to an individual 'sport cabin' in which they are standardly exposed to infrared light.

OTHERsupervised non-infrared exercise group

Participants of the intervention group will be asked to perform 1-3 exercise sessions per week at the Infraligne center of Genk, Hasselt or Maasmechelen for a total duration of 12 weeks. Participants assigned to the supervised non-infrared exercise group will exercise in the sport-cabin with the infrared light turned off.

OTHERControl group

Participants of the control group are advised to perform moderate intensity aerobic exercise at least 3 days per week for an average of 30-50 minutes per session and a total duration of 12 weeks.