F18-MHF: Orthopedic Implants-Associated Infection Detection
Phase II Investigation of [F-18]MHF as a PET Tracer to Detect Orthopedic Implants-associated Infection
Emory University
30 participants
Nov 4, 2024
OBSERVATIONAL
Conditions
Summary
Following intravenous injection of \[F-18\]MHF as a bolus, dynamic PET imaging of the lower limbs will be acquired for approximately 90 minutes. The acquired images will be processed and viewed on a MIMVista or similar workstation. The uptake pattern of \[F-18\]MHF around infected orthopedic knee implant will be determined and compared with its uptake pattern around non-infected knee implants. This study will look at how \[18F\]MHF goes into normal knee replacements and those with suspected infection.
Eligibility
Inclusion Criteria5
- Patients must be 18 years of age or older, able to provide written informed consent, and ability to lie still for PET scanning.
- Suspected knee prosthetic infection at least 2 months after original prosthesis placement and who are scheduled to undergo surgery debridement/removal based on the clinical assessment of the referring surgeon.
- Elevated CRP and ESR
- Patients must be 18 years of age or older, able to provide written informed consent and ability to lie still for PET scanning
- Knee prosthesis in situ without complications for 6 months or longer
Exclusion Criteria6
- Undergoing current or recent antimicrobial therapy (within 1 month)
- Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes
- Other clinically likely site of infection
- Clinical or laboratory suspicion of knee prosthesis infection
- Recent (within 3 months) or current treatment for infected knee prosthesis
- Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes
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Interventions
Following intravenous injection of 10 ± 2 mCi (370 ± 74 MBq) \[F-18\]MHF as a bolus, dynamic PET imaging of the lower limbs will be acquired for approximately 90 minutes. The acquired images will be processed. The uptake pattern of \[F-18\]MHF around infected orthopedic knee implant will be determined and compared with its uptake pattern around non-infected knee implants.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05889286